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At the mechanistic level, RNA-binding protein QKI regulates macrophage polarization, and TLR4 single nucleotide polymorphisms (SNPs) reveal genetic susceptibility [381], providing molecular and genetic foundations for precise intervention

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Glaucoma involves cytokine release driven by inflammation triggered by abnormal processing of amyloid precursor protein and subsequent deposition of A and p-Tau in retinal ganglion cells, which disrupts iron homeostasis and leads to retinal iron overload