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The most common causes of oral pigmentations are genetic, related to ethnicity, and those caused by accidental amalgam implantation (Table 221)

This binding activates MPST, which produces hydrogen sulfide (HS) and pyruvate, boosting mitochondrial respiration

The role of mitochondrial transcription factor B2 (TFB2M), another regulator of mitochondrial gene expression, was observed in mouse TFB2M-KO -cells which had impaired mitophagy via defects in autophagosome-lysosome fusion, and this was associated with mitochondrial dysfunction, and deficient insulin release (Nicholas et al., 2017)