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It is driven by iron-dependent phospholipid peroxidation and regulated by several cellular metabolic events, including redox homeostasis, iron handling, mitochondrial activity, and metabolism of amino acids, lipids and sugars [67]

10.1002/jcp.31100 110 SulO.-J.RaS

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In the absence of efficient repair mechanisms, cell membranes in yeast cells are oxidized, the structure and function of proteins are modified, and DNA is damaged [16]