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Of the 60 voluntary participants in this study, those who took hyaluronic acid showed a significant reduction in the depth and length of the wrinkles, compared to those who took placebo as established by microscopic examinations

Interestingly, in sunitinib-treated mice, there is a higher infiltration of CD4 + and CD8 + within the tumor with a lower CTLA-4 and PD-1 expression, preventing T cells exhaustion [86]

Mol Biol Cell 19:20142025 Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE et al (2017) Oxidative stress, inflammation and treatment response in major depression