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According to a recent study, NOX enzymes perform various functions in atherogenesis (Poznyak et al., 2020b) XO utilizes the molecule oxygen as an electron acceptor to generate hydrogen peroxide and superoxide (Letourneau et al., 2021) Endothelial XO expression is increased in response to proatherosclerotic stimuli such as angiotensin II (Ang II) treatment and oscillatory shear stress (Polito et al., 2021)

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