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Psychiatry (2016) Samara, M

Recommendations for the definition, evaluation, and treatment of nail psoriasis in adult patients with no or mild skin psoriasis: A dermatologist and nail expert group consensus

Upon activation, LXR induces cholesterol efflux and lipogenesis, but also exerts antiproliferative effects by downregulating cell cycle regulators such as S-phase kinase-associated protein 2 (Skp2), c-Myc, CDKs, and cyclins, and inducing hypophosphorylation of the tumor suppressor retinoblastoma protein (Rb), thereby halting epithelial cell proliferation [13, 14]

Alternatively, when cancer cells use GSH as a cysteine source, they rely less on these pathways (that is, xCT and TXNRD1)

Importance in the metabolic control of diabetes