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These integrative insights guide the adoption of optimized regimens, including combination therapy with biologics and immunosuppressants [573], switching to JAK inhibitors(tofacitinib, upadacitinib) [554, 574], or microbiota-directed interventions such as probiotics and fecal microbiota transplantation [575]

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Approximately 95% of the body's carnitine is stored in skeletal muscle, with the remaining 5% distributed among cardiac muscle, brain, liver, and testes tissues with very high energy demands that depend on carnitine for optimal function.

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