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Interestingly, Abd El-Aziz et al

120 Prolonged (more than 1.5 hours), high-intensity exercise is not recommended for people with HIV, as it may have an immune-suppressing effect

Finally, RBCs are also important carriers of hormones, folate, drugs (e.g., valproate, phenytoin, and hydrocortisone), and small metabolites that play key roles in gas exchanges (Highley and De Brujin, 1996)