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The interaction and mutual promotion of these three factors are thought to be responsible for the concentrated epidemic of cretinism in Central Africa ( Figure 2 It is thought-provoking that Se supplementation in iodine-deficient populations in this region can have serious and incalculable consequences ( This enlightens us that Se supplementation should not be done indiscriminately in patients with congenital hypothyroidism (CH)

In experimental research, the blend may be used in slow-response tissue models to evaluate signaling and structural responses over time

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