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Different molecular cascades are crucial for normal cell growth and cell-to-cell communication [2] so that changes in such signaling pathways can trigger tumor heterogeneity and aggressiveness [3]

) Method for preparing in vivo formulation: Take L DMSO master liquid, next addL PEG300, mix and clarify, next addL Tween 80, mix and clarify, next add L ddH 2 O, mix and clarify

the Met + Pio group ( n = 75) received metformin plus pioglitazone (500 mg, 15 mg, respectively) and placebo (citric acid plus calcium carbonate), twice daily for 12 weeks