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Sustained hyperglycemia and the accumulation of advanced glycation end products (AGEs) cause chronic inflammation and pro- mote excessive production of reactive oxygen species (ROS), This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited

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Neurologic complications are not always associated with megaloblastic anemia and are the only clinical symptom of vitamin B 12 deficiency in about 25% of cases (21)

ARA-290 Peptide and Retinal Ischemia A recent study (6) has suggested that ARA-290 may have the potential to protect the endothelial blood vessels and possibly thereby combat retinal ischemia in models of ischemic retinopathies