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Clinical trials Although several studies using in vitro and in vivo experimental models have reported the protective effects of polyphenols in CFS and muscle atrophies, human use is still scarce in this area, perhaps due to ambiguities in polyphenol bioavailability, doses, and lack of efficacy in humans (Nikawa et al

[DOI] [PubMed] [Google Scholar] 21.Lodge JK, Packer L

Alkhdairi Acquisition, analysis, or interpretation of data: Ayadi Yacine, Muhammad Zain Ali, Amal Bayen Alharbi, Huda Qubayl Alanaz, Ahmad Saud Alrahili, Ahmad A

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This treatment aligns with a hub transcription factor cascade involving WRKY, NAC, and bZIP families that correlates with the up-regulation of Ribosome biogenesis in eukaryotes and Protein processing in endoplasmic reticulum genes, alongside downstream functional genes (e.g., AmISD1 , AmID1 ) implicated in photosynthesis and antioxidant defense