EU/3/07/502 - orphan designation for treatment of small cell lung cancer
Previous systematic reviews reported that neuropsychiatric disorders, such as Alzheimers disease and autism, often share similar pathologies in mitochondrial dysfunction 43 regarding energetic metabolic abnormalities
In the case of AL, pharmacokinetic modeling of steady-state concentrations shows that regimens using the three injection intervals, in combination with specific dosage strengths, all provide adequate plasma concentrations of aripiprazole for the full course of the injection interval.Reference Hard, Mills, Sadler, Turncliff and Citrome 17 , 18 , Reference Hard, Mills, Sadler, Wehr, Weiden and von Moltke 20 , Reference Hard, Wehr, Sadler, Mills and von Moltke 21 When prescribing an AL regimen, clinicians can weigh this information, together with patient factors, to help make better choices for their patients clinical circumstances
Venugopal S, Jabbour E, Pemmaraju N, Montalban-Bravo G, Chien K, Daver N, Jain N, Burger J, Alvarado Y, Maiti A, DiNardo C, Borthakur G , Malla R, Garcia-Manero G, Ravandi F, Kantarjian H, Kadia T
Congestive heart failure does not go away on its own and is generally a progressive, lifelong condition