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The cystine transporter SLC7A11 critically restores/maintains intracellular GSH

In most people with variegate porphyria signs and symptoms may only become apparent when they are exposed to non-genetic factors such as certain drugs, stress, dieting or fasting, and certain hormones

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Silymarin works by stabilizing liver cell membranes, making it harder for harmful substances like alcohol, pollutants, or medications to enter and damage liver cells

Although mechanisms describing the interaction between the key pathway constituents Nrf2, Keap1 and p62 are widely reviewed and discussed in literature, quantitative dynamic models bringing together these mechanisms with time-resolved data are limited