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Results of a comparative trial of idarubicin and cytarabine with daunorubicin and cytarabine in patients with untreated acute nonlymphocytic leukemia

This finding also suggests that inhibition of FDPS by zoledronate results in cytotoxic effects in addition to the anti-proliferative effects caused by its depletion of GGPP

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Upon entering the cytosol, mtDNA can trigger responses by activating four innate immune receptors: cytoplasmic cyclic GMP-AMP synthase (cGAS), TLR9, absent in melanoma 2 (AIM2), and NLRP3