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PHGDH enzyme: a novel target for cancer treatment The serine synthesis pathway has been widely reported to be strongly associated with cancer proliferation and metastasis, although the specific mechanism underpinning the functional addiction of some tumour cells to serine remains uncertain 11

The Mediterranean diet emphasises the consumption of plant-based foods such as fruits, vegetables, whole grains, legumes, and nuts and seeds

Widespread chromosomal abnormalities, including losses on chromosomes 9 and 10 and polysomy of chromosomes 7, 19, and 20, are recurrently observed in GBM

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The TCA cycle is completed by MDH, which, as a salt-sensitive enzyme, is thought to play a protective role by counteracting the damaging effect of salt by increasing the malate through conformational change (Saha et al., 2012)