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In brief, the first and rate-limiting step is the abstraction of a hydrogen atom by non-heme ferric iron (Fe(III)), involving a proton-coupled electron transfer in which the electron is transferred directly to the iron and the proton is acquired simultaneously by the hydroxide ligand in a concerted mechanism to give a substrate radical, while the iron atom is reduced to the ferrous state (Fe(II))

HIF stabilisers are emerging as an innovative therapeutic strategy for the treatment of IBD ( In vivo studies with 4-mercapto butyrate confirmed this pattern for systemic HIF stabilisation in mice (Ornelas et al., 2023)

9 (6), 360370 (2012) S.N

36 MatsudaF.SakakimaH.YoshidaY

Allegaert, K