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Nrf2 is a key transcription factor with a basic-region leucine zipper (bZIP) structure in the Cap-n-Collar (CNC) family, which controls many aspects of cell homeostasis in response to oxidative stress and toxic insults in various tissues and cells (Skibinski et al., 2017

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Zn also has antioxidant properties through influencing glutamate-cysteine ligase expression, it is the enzyme that limits the rate at which glutathione is synthesized from scratch

8 Therefore, we hypothesized that GSTP1 might be involved in the progression of CRC by regulating STAT3

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