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These findings are complemented by neuropathological evidence from postmortem studies, where chronic alcoholics show reduced density of serotonin (5-HT) transporters in the raphe nuclei and diminished hippocampal neurogenesis, paralleling changes seen in depressed individuals without AUD (Pierson et al

These agents should also have high photostability to resist photobleaching and high absorbance in the 600-850 nm range to balance tissue transparency and photoreaction requirements, especially for producing 1 O 2