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Importantly, all three markers are upregulated in vehicle-treated N1IC cells compared to p53 cells, further suggesting low level baseline ferroptosis in the AC-like cell state

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These studies assess parameters like bone density, nerve regeneration markers, and inflammatory cell infiltration

Studies link IGF-1 deficiency to impaired lipid profiles, insulin resistance, and cardiovascular risks

The study was conducted in accordance with the ethical principles that have their origins in the Declaration of Helsinki and its subsequent amendments (clinicaltrials.gov identifier NCT02317536)