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Multiple tumor suppressors that repress PI3K/AKT/mTOR and HIF-1 signaling are epigenetically silenced by promoter hypermethylation, including PTEN 126, 127, 128, 129, 130 , LKB1, 131, 132 VHL 133, 134, 135, 136 and prolyl hydroxylases (PHD1/2/3)

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The following sections examine (1) the metabolic characteristics and mechanisms of BCAAs, (2) their regulatory roles within the musclebrain axis, and (3) the combined effects of BCAA supplementation and exercise on energy metabolism, physical function, and cognitive health in aging populations

Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or References Eriksson J, Franssila-Kallunki A, Ekstrand A, Saloranta C, Widen E, Schalin C, et al