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Understanding the differences in classification among all opioid classes has implications for clinicians, as differences in chemical structures result in varying receptor affinities, potencies, pharmacokinetic characteristics, and risk profiles (6)(7)(51)

Timeframe Weeks 1-2 Commonly tracked Range-of-motion and functional self-report in case series Notes Reflects symptom-level changes, not structural healing

Secondary metabolic markers include fasting glucose, insulin sensitivity via HOMA-IR or glucose tolerance testing, body composition changes (DEXA scan or MRI for fat mass and lean mass distribution), mitochondrial respiration capacity via Seahorse analyzer, and serum markers like HbA1c for long-term glucose control

We will continue to engage with interested parties to assess the appropriate level of code stratification and will address any potential refinements through future rulemaking