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These mechanisms are highly interconnected: A deposition can trigger neuroinflammation and oxidative stress, tau pathology contributes to synaptic and mitochondrial dysfunction, and genetic risk factors further influence immune and endosomallysosomal pathways

Outcomes of patients with blastoid and pleomorphic variant mantle cell lymphoma

Some of the resulting organic acids are thought to bear a direct toxicity to mitochondria, which leads to dysfunction of high energy-demanding organs such as the heart, the optic nerve, the liver, the brain, and the hematological precursor cells

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