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1.2 Chronic lung disease NTHi is the leading bacterial cause of infectious exacerbations in adults with chronic obstructive pulmonary disease (COPD) and the second leading cause of infections in paediatric cystic fibrosis (Marshall et al., 2022)

2025;82:103593.[DOI] 151

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All NADPH oxidase isoforms share a common structural homology, featuring a catalytic core composed of six transmembrane helices chelating two hemes and a dehydrogenase domain (DH) that binds the non-covalently linked flavin cofactor (FAD) and the NADPH substrate [25]