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This lack of energy may make it difficult for individuals to engage in regular physical activity, potentially leading to weight gain

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Gastrointestinal disorders were the most common adverse events with semaglutide, typically transient, of mild-to-moderate severity, occurring during dose escalation, and infrequently leading to treatment discontinuation

Analysis of the data indicates that short-term treatment with RM-493 increased resting energy expenditure significantly (by 6.4% vs placebo), thus suggesting RM-493 may be clinically effective for treating obesity

It is important for each patient to participate in healthy habits and work with their doctors to address underlying conditions that may affect metabolism or energy levels