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Nevertheless, more advanced research should be done regarding the supplementation of vitamin B12 for tHcy lowering to determine the optimal dose (Fig

Nutrient depletion from stress or diet

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On the basis of the hypothesis that enhancing serotonergic neurotransmission would be a viable mechanism to mediate antidepressant response, efforts to develop agents that inhibit the uptake of serotonin from the synaptic cleft were initiated at Eli Lilly in the early 1970s