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The LAT subunits are members of the amino acid polyamine cation (APC) superfamily 32 , which exhibit a conserved 5 + 5 inverted topology fold, wherein the first five TM helices are related to the second five helices via a pseudo two-fold symmetry axis running parallel to the plane of the membrane 33

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2.10 Overexpression and knockdown of RRM2 gene in TPC-1 and IHH4 cells For upregulating RRM2 expression in cells, we obtained a full-length RRM2 sequence fragment using a PCR method and subsequentlycloned it into vector LV18, verified by DNA sequencing and transfected 293T cells (see Supplementary Materials for details)

Administration of GA prevented ISO-induced (Group IV) interstitial collagen accumulation (Figure 8D)

It may also reflect partial aggregation or limited silver ion release under the test conditions