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Planta Med 61:3336

Evidence suggests that SLE patients may suffer chronic microbial translocation through impaired gut barrier integrity contributing to immunologic dysregulation (159)

doi: 10.3389/fimmu.2023.1114870 Received 05 December 2022 Accepted 05 May 2023 Published 22 May 2023 Volume 14 - 2023 Edited by Alan Landay, Rush University, United States Reviewed by Sudhanshu Bhushan, University of Giessen, Germany

HIF-1-dependent induction of retinoic acid-receptor-related orphan receptor-t (RORt) combined with targeting FOXP3 for degradation is detrimental to Treg cells and fosters Th17 cell generation (84), identifying hypoxia as a potent risk factor for unrelenting inflammation