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This allows cancer cells to neutralize ROS generated by rapid cell division and metabolic activity, contributing to chemoresistance in PDAC [66,67]

Challenges and perspectives The rapid advancement in molecular, biological, and genetic diagnostic technologies has sparked extensive exploration into diagnostic and imaging identification patterns within the lymphatic system, as well as investigations into its role in cancer initiation, progression, and metastasis

High-level ROS not only act as a catalyst for ferroptosis but also directly phosphorylate RIPK3, thereby triggering necroptosis

In conditions where glutamine metabolism is inhibited, these adaptive responses can be compensated for via glutamine metabolism bypass pathways or by circumventing glutamine metabolism, thereby rewiring them to survive and proliferate [211]

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