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In addition, decreased glucose uptake is strongly associated with reduced protein O -GlcNAcylation that directly links altered brain metabolism with AD pathological hallmarks (395, 396)

Night shift work increases the risk of irritable bowel syndrome, which is mediated by inflammation

In the central nervous system (CNS), both cell replacement and tissue engineering strategies are being vigorously pursued to facilitate regeneration of native tissue and/or to directly restore lost function based on permanent structural integration

Thus, it is reasonable to assume that improved symptomatology is explained mainly by the psychological intervention alone

In the acute phase of infarction its core shows signs of anaerobic metabolism and cell death