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HYP can successfully reach the brain through the BBB, and the metabolic process is rapid, reaching a peak value about 0.5 h after entering the brain, and the basic metabolism is complete within 3 h (100) (see Table 6 )

A series of systematic reviews was conducted to evaluate the hypothesis that DHEA or DHEAS levels are associated with ASD, autism spectrum traits, or aspects of brain development relevant to autism

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