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TNF- upregulates epithelial adhesion molecules, promotes inflammatory cell recruitment and activation, and induces inflammatory mediator release, resulting in tissue damage [98]

Because cagrilintide has a 7- to 8-day half-life, published label guidance describes taking a missed dose as soon as possible if the next scheduled dose is more than 3 days away, or skipping it if the next dose is closer than 3 days

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1 2 Nature Structural & Molecular Biology