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The following sections will delve into the peripheral and molecular mechanisms underlying PD, thereby establishing a foundation for mechanismdriven preventive and therapeutic approaches

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Glutathione peroxidase (GPx) is a crucial antioxidant enzyme vital in detoxifying ROS and preventing oxidative damage, by converting it to water using reduced glutathione (GSH) as a substrate (21)

PDI in its reduced state can be oxidized ( i.e

Besides, long-term monitoring of patients immune system status is essential, with particular emphasis on the quantity, types, and functionality of regenerated B cells, as well as changes in T cell subsets, to assess the duration and quality of immune system reconstitution