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A.IshiokaY.KuroiwaM.SahmD

10.1016/S2213-2600(22)00260-0 113 SpagnoloP.KropskiJ

To preserve and stabilize enzymes in formulation, technologies have been developed, among them encapsulation using liposome or nanoemulsion, addition of sugar or polyol as cosolute strengthening the hydration shell around the enzyme, or precise pH control matching the isoelectric point ensuring structural stability [193, 194]