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10.3390/cancers12010164 Cancers 9 BjrklundG.TinkovA.KizekR.AjsuvakovaO.ChirumboloS.SkalnayaM.et al (2020)

Randomised clinical trial: vercirnon, an oral CCR9 antagonist, vs

Cytokines secreted by activated macrophages can also interfere with myelination and the expression of related genes (247), preventing myelin sheath repair and causing disability (248)

These findings have led to the consensus that elevated plasma total homocysteine is a modifiable risk factor for development of cognitive decline, dementia, and Alzheimers disease in older persons