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These cardioprotective effects were abolished in mice lacking Atg5 in cardiomyocytes (232), supporting the notion that induction of autophagy by spermidine may be useful to prevent CVD

In immune cells, these processes are essential for preventing metabolic exhaustion and maintaining immunological vigilance (Steinert et al., 2021)

27 This downregulation may be due, in part, not only to the formation of histone adducts but also to the decrease in the expression of histone acetyltransferases

induction of inflammation (e.g., Bacteroides fragilis-triggered, IL-17-dominated mucosal inflammation promoting epithelial mutations) (351)