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E.MajounieE.WaiteA.Simn-SnchezJ.RollinsonS.GibbsJ

Lung function Spirometry, including measurement of forced expiratory volume in one second (FEV 1 ), forced vital capacity and bronchodilator responsiveness, should be performed in all patients at diagnosis and repeated in monitoring on an annual basis

Moreover, acetyl-l-carnitine is an epigenetic regulator of genes involved in analgesia such as the metabotropic glutamate 2 receptor in the presynaptic neurons and of neurotrophic factors including nerve growth factor