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These findings suggest that ACSF2 may alleviate inflammatory responses in IBD and delay the progression of experimental colitis by inhibiting ferroptosis pathways

82272990), Health and Medical Research Fund (HMRF, 08190586), CUHK direct grant (2022.001 and 2020.004), and Cheng Yue Pui Charity Foundation

Our results uncover tissue-specific transcriptional activation as the result of ubiquitous actuator TFs harnessing general transcriptional activator at tissue-specific enhancers, to which they are directed by binding with lineage- and domain-specific TFs