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While HIV-1 cannot directly infect B cells, the ability of its Tat protein to enter these cells and interfere with DNA repair mechanisms is believed to contribute to lymphomagenesis

Sirtuins, particularly SIRT1 and SIRT3, protect cells from oxidative stress by increasing the activity of antioxidant enzymes, including superoxide dismutase 2 (SOD2) and CAT (127, 131, 132)

142 Therapy for hyperbilirubinemia and neonatal hemolysis resulting from G6PD deficiency includes the following: phototherapy or exchange transfusion to prevent kernicterus

However, there are multiple ways that cells can balance ROS and combat oxidative stress

Sangkum, P