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Figure 2 Figure 3 Ferroptosis is associated with the occurrence and progression of multiple diseases, including cardiovascular diseases, kidney diseases, gastrointestinal disorders, cancers, and various neurodegenerative diseases (Wu et al., 2021

doi: 10.3389/fendo.2021.620920 295 DupuisMLContiFMaselliAPaganoMTRuggieriAAnticoliSet al

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NADP generally serves in biosynthetic (anabolic) reactions, such as in the synthesis of fatty acids, steroids (e.g., cholesterol, bile acids, and steroid hormones), and building blocks of other macromolecules (4)

Metal accumulation in fish tissues depends on the metal concentration, exposure time, manner of metal uptake, environmental conditions (e.g., water temperature, pH, hardness, salinity), as well as intrinsic factors such as fish age and feeding habits ( Campana et al., 2003 )