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15 Collectively, these events lead to a vicious cycle of persistent inflammation and chronic oxidative stress, which results in protease-anti-protease imbalance, defects in tissue repair mechanisms, accelerated apoptosis in lung cells and progression of COPD

However, due to the lack of a placebo control and inherent biases of unblinded designs, these findings remain preliminary and insufficient to support clinical use (168)

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Most patients report feeling normal during the administration

When IgG4-RD involves the central nervous system or surrounding areas, it may cause: Persistent headaches Eye pain or swelling Facial numbness Neurological symptoms like vision or hearing changes Chronic sinus problems These symptoms may resemble migraines, tension-type headaches, or sinus infections, which is why understanding the link between IgG4-RD and chronic headaches is essential