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Miyamoto K, Nakanishi H, Moriguchi S, Fukuyama N, Eto K, Wakamiya J, Murao K, Arimura K, Osame M (2001) Involvement of enhanced sensitivity of N-methyl-d-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity

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The scientific rationale for combining these peptides stems from research demonstrating that GHRH and GHRP pathways act synergistically: GHRH primarily stimulates GH synthesis and amplifies GH pulse amplitude, while GHRPs modulate pulse frequency and timing by acting on distinct receptors and intracellular signaling cascades