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They differ significantly in their composition, clinical evidence base, and cost

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In addition to the co-delivery of therapeutic agents with siRNA or new-generation potent P-gp inhibitors mentioned above, co-delivery of therapeutic agents with natural alkaloids (such as tetrandrine, quercetin (QUE), kaempferol, and icaritin) may be a good strategy when facing the failure of first- and second-generation P-gp inhibitors (such as verapamil, cyclosporine A, and dexverapamil) ( 2.2 Inducing cell apoptosis in cancer therapy Apoptosis is programmed cell death that is initiated after damage to DNA and cell organelles, such as the mitochondria and endoplasmic reticulum ( In vivo TUNEL assays also showed that tumors in the CDDP/CUR-Lip group had the largest proportion of apoptotic tumor cells