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This loss primarily occurs due to co-deletion of the Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A) genewhich encodes the p16 tumor suppressor proteinor through promoter methylation of the MTAP gene (5)

Sequence GEPPPGKPADDAGLV

Cudkowicz, citing the Healey ALS Platform Trial, which allows for testing of more than one drug at a time, with a single placebo group for comparison

Notably, D3T exhibits neuroprotective effects in neuroinflammation and IS, suggesting its potential as a treatment option for ferroptosis-related diseases