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Nigellamines, which are the main alkaloids, and polyphenols, such as quercitrin and kaempferol, have been identified in Nigella sativa

54 ) were cultured in DMEM medium with 10% fetal bovine serum and transfected with a pCMV(d1)-PINK1-3HA plasmid for 14 h at 37 C and 5% CO 2 in a humidified atmosphere

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Figure 1: Changes in concentrations of estradiol and progesterone in control and FSH-4.4 groups

In MCF-7 and MDA-MB-231 cell lines, the combination of abemaciclib with IRR (10 Gy) incited a significant diminution in the gene expressions of CDK4, CDK6, TGF-1, and NF- comparable to abemaciclib-treated cells (Fig