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Symptoms of vitamin B12 deficiency can include fatigue, weakness, tingling or numbness in the extremities, difficulty walking, mood changes, and memory problems

Aging of the immune system

Prof Douglas Higgs, also from Oxford University, pointed out that not all the patients had become free of transfusions and there was still little known about the long-term effects of manipulating the genome of stem cells in this way

The model identifies pathways responsible for the effect of the double and triple drug combinations, versus the effect of the addition of each single agent at its IC50 concentration