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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

Reviews typically cant control for confounders (diet changes, exercise, stimulant intake, sleep, stress, or other supplements), and negative experiences are often underreported

What matters far more than the exact route is whether you needed the injection in the first place, and whether the dose and schedule are right

[DOI] [PubMed] [Google Scholar] 55.Roberts T

However, there is another popular reason why most people use vitamin B12 injection, and that is to help them lose weight