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Thomas TP, Grisanti LA

It usually presents with pathological changes of glomerular filtration rate below 15 ml/(min1.73m^2), accompanied by retention of metabolites and toxins, and disturbance of water, electrolyte and acid-base balance as the main clinical features (Wouk, 2021)

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Bennett BJ, de Vallim TQ, A, Wang Z, et al (2013) Trimethylamine-N-Oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation

--- ## Safety, Side Effects & Monitoring ### Common Side Effects | Peptide | Common Effects | Management | |---------|---------------|------------| | CJC-1295 | Mild fatigue, water retention | Reduces over time | | Ipamorelin | Headache (rare), injection site reaction | Very well tolerated | | GHRP-6 | Intense hunger, water retention | Discuss with your provider | | IGF-1 LR3 | Hypoglycemia risk, joint pain | Requires monitoring | ### Safety Protocols 1