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She had no significant medical history and was afebrile

Due to change in size and shape, the movement of red blood cells from bone marrow to the bloodstream become ineffective, often leading to megaloblastic anemia

Whilst vitamin B12 toxicity is exceptionally rare due to its water-soluble nature, very high levelsparticularly from mega-dose supplements or frequent injectionshave been associated with certain adverse effects, most notably skin reactions

This means very small amounts may have strong biological effects

Metabolism and Cellular Bioenergetics NNMT activity is closely linked to nicotinamide metabolism, an important component of the NAD