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Furthermore, Zhang et al

Protocol adjustments Initial protocols sometimes need adjustment

1 Introduction Berberine (C 20 H 18 NO 4 , IUPAC name: 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo [11.8.0.0 2,10 .0 4,8 .0 15,20 ] henicosa-1(13),2,4(8),9,14,16,18,20-octaene, PubChem CID: 2353), an isoquinoline quaternary alkaloid, isolated from different medicinal plants with a molar weight of 336.36 g/mol, including Hydrastis canadensis , Xanthorhiza simplicissima , Berberis aristata , Coptis chinensis , Coptis japonica , etc

However, about 30% of patients develop recurrence of PSC (rPSC), which negatively impacts the outcome of liver grafts and patients

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